Table 2 Residues that are correctly identified as critical only by the rigidity analysis (top 5) or conservation analysis (bottom 14).
From: A conservation and rigidity based method for detecting critical protein residues
PDB ID | WTResidue | WT ResidueHydrophobicity | ΔΔG | Change to LRB upon in-silico mutation to glycine |
|---|---|---|---|---|
1stn | D95 | - | -3.1 | 5 |
1iob | T9 | very | -2.6 | 7 |
2rn2 | S68 | - | -2.4 | 12 |
1rtb | V16 | very | -1.18 | 9 |
3mbp | V8 | very | -1.0 | 6 |
1stn | L37 | very | -3.9 | 0 |
1stn | T62 | - | -3.4 | 0 |
3mbp | A276 | slight | -1.5 | 0 |
2rn2 | A52 | slight | -2.7 | 0 |
1ftg | A84 | slight | -1.25 | 0 |
1cto | V45 | very | -1.9 | 0 |
1stn | L36 | very | -5.4 | 0 |
1rtb | V54 | very | -4.87 | 0 |
1rtb | P93 | - | -2.6 | 0 |
1lz1 | P103 | - | -0.1 | 0 |
1rtb | P114 | - | -3.6 | 0 |
1lz1 | P71 | - | -1.6 | 0 |
1iob | P97 | - | -1.2 | 0 |
3ssi | V13 | very | -9.3 | 0 |