Table 3 Rigidity analysis and conservation score analysis for proteins with residue mutations to glycine.
From: A conservation and rigidity based method for detecting critical protein residues
PDB ID | Mutation (WT, residue number, mutant) | WTResidue SASA (Å2) | ΔΔG | % Decrease ofLRB when WT residue in-silico mutated to glycine | Critical by Conservation Score Analysis | Detected critical by Conservation Score or Rigidity Analysis | No. of Binding Partners |
|---|---|---|---|---|---|---|---|
1bpi | N43G | 0.0 | -5.7 | 1.39 | Yes | True Positive | 0 |
1bpi | Y35G | 14.74 | -5.0 | 0.0 | Yes | True Positive | 2 |
1lz1 | V2G | 191.52 | -2.3 | 0.0 | No | False Negative | 0 |
1lz1 | V74G | 156.35 | -0.22 | 0.0 | No | False Negative | 1 |
1lz1 | V110G | 181.77 | 0.48 | 1.93 | No | False positive | 0 |
1lz1 | P71G | 72.63 | -1.6 | 0.29 | Yes | True positive | 1 |
1lz1 | P103G | 146.25 | -0.1 | 0.37 | Yes | True positive | 0 |
2rn2 | K95G | 142.44 | 1.7 | 0.0 | No | True Negative | 0 |