Table 5 Rigidity analysis and conservation score analysis for protein 2abd and 1csp, with residue mutations to alanine.
From: A conservation and rigidity based method for detecting critical protein residues
PDB ID | Mutation (WT, residue number, mutant) | WT Residue SASA (Å2) | ΔΔG | % Decrease ofLRB upon in-silico mutation of residue to alanine | Critical by Conservation Score Analysis | Detected critical by Conservation Score or Rigidity Analysis |
|---|---|---|---|---|---|---|
2abd | E67A | 99.97 | -0.36 | 0 | No | False Negative |
1csp | F17A | 57.18 | -0.81 | 4.33 | No | True Positive |
2abd | K54A | 49.09 | -0.86 | 1.98 | Yes | True Positive |
1csp | F27A | 70.65 | -0.89 | 0 | Yes | True Positive |
1csp | F15A | 50.5 | -0.96 | 2.96 | No | True Positive |
2abd | K32A | 63.06 | -1.02 | 1.18 | Yes | True Positive |
2abd | L25A | 15.81 | -1.02 | 3.76 | Yes | True Positive |
2abd | P44A | 49.62 | -1.04 | 3.06 | Yes | True Positive |
2abd | P19A | 5.59 | -1.07 | 0 | Yes | True Positive |
2abd | T35A | 51.06 | -1.09 | 0.69 | Yes | True Positive |
2abd | V77A | 8.94 | -1.14 | 0.59 | Yes | True Positive |
2abd | V12A | 8.78 | -1.69 | 2.37 | Yes | True Positive |
2abd | Y28A | 50.63 | -2.47 | 1.28 | Yes | True Positive |
2abd | L15A | 0.0 | -3.1 | 1.18 | Yes | True Positive |
2abd | Q33A | 1.59 | -3.66 | 0.99 | Yes | True Positive |
2abd | L80A | 3.15 | -3.7 | 3.26 | Yes | True Positive |
2abd | Y73A | 4.5 | -4.83 | 1.28 | Yes | True Positive |