Figure 8
From: Unbiased, scalable sampling of protein loop conformations from probabilistic priors
Closed-chain sampling. Three sampling methods for a 20-link closed-loop chain. At left, the prior gives preference to joint angles with small magnitude. At right, the prior gives preference to joint positions in a triangle shaped distribution (circle centers: means, shaded circles: 3σ spreads). Top: sampling joint angles followed by numerical loop closure, best 20/20,000 samples. Middle: sampling with RLG [5], best 20/20,000 samples. Bottom: SLIKMC, displayed every 40'th sample. These sample sets are generated by our method approximately as fast as RLG and an order of magnitude faster than numerical loop closure.