Table 1 Characteristics of loop generation techniques
From: Unbiased, scalable sampling of protein loop conformations from probabilistic priors
Technique | Loop closure | Prior distribution/energy function | Global search | Scalability |
|---|---|---|---|---|
Optimization | Exact | Y | N | + |
Inverse kinematics sampling | Exact | N | Y | ++ |
Discrete search | Inexact | Y | Finite subset | - |
Standard Monte Carlo | No | Y | Y, reqs. mixing | + |
SLIKMC | Exact | Y | Y, reqs. mixing | ++ |