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Figure 6 | BMC Structural Biology

Figure 6

From: Structural insights into Noonan/LEOPARD syndrome-related mutants of protein-tyrosine phosphatase SHP2 (PTPN11)

Figure 6

N308D mutation alters the local hydrogen bond network. a) In WT SHP2, the side chain of Asn308 forms two hydrogen bonds with Phe285 in the pTyr-loop (colored in yellow). It also forms a hydrogen bond with the conserved Arg501 which, in turn, makes two direct hydrogen bonds with the main chains of Ala461 and Gly462 in the catalytic P-loop (colored in magenta); b) In the N308D mutant, besides the aforementioned hydrogen bonds, Asp308 forms two additional hydrogen bonds with surrounding residues, most notably, a strong hydrogen bond with Thr288 (2.5 Å).

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