Design strategy and crystal structure of YopM-InlB. Domain organization of full-length InlB (InlB-fl), InlB321, YopM and the two hybrid proteins. LRRs are numbered in InlB but not in YopM. The structure of wild type InlB321 (PDB ID 1h6t) is shown on the bottom left. Residues 93–321 are highlighted in green. YopM (PDB ID 1jl5) is shown on the right. Residues 34–87 comprising the cap and LRR1 are highlighted in orange. The actual crystal structure of the hybrid protein YopM-InlB is shown in the middle.