Table 5 Identical sequences between transgenic- and allergenic proteins of special interest
Transgenic protein (1) | Identical peptide | Allergens (2) | Remark |
|---|---|---|---|
Insecticidal protein Cry1Ac (Bacillus thuringiensis kurstaki HD-73) | GNAAPQ GSTGITI | Cedar pollen allergens Cup a 1, Jun a 1, Jun o 1, Juniperus virginiana 1–1, and Juniperus virginiana 1–2 | Two sequences shared with same allergens, potential crosslinking of IgE if bound by both sequences |
Papaya Ringspot Virus coat protein | EKQKEK | Nematode allergen ABA-1 (Ascaris suum, A. lumbricoides) | Sequence predicted to be antigenic determinant of allergenic protein (Figure 4) |
Acetolactate synthase (GH50 mutant, Arabidopsis thaliana) | KVLENR (3) | Shrimp allergen Met e 1 Lobster allergens Hom a 1 and Pan s 1 Crab allergen Cha f 1 | KVLENR is part of 15-mer peptides that are recognised by sera from allergic patients [28, 29] |
Glyphosate oxidoreductase (Achromobacter LBAA) | LAEEAD | Shrimp allergen Met e 1 Lobster allergens Hom a 1 and Pan s 1 Crab allergen Cha f 1 Fish parasite allergen Ani s 3 | LAEEAD is part of 9-mer peptide from the shrimp tropomyosin allergen Pen i 1 that is bound by sera from shrimp allergic patients [26, 27] (4) |