TY - JOUR AU - Wlodawer, Alexander AU - Durell, Stewart R. AU - Li, Mi AU - Oyama, Hiroshi AU - Oda, Kohei AU - Dunn, Ben M. PY - 2003 DA - 2003/11/11 TI - A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases JO - BMC Structural Biology SP - 8 VL - 3 IS - 1 AB - Tripeptidyl-peptidase I, also known as CLN2, is a member of the family of sedolisins (serine-carboxyl peptidases). In humans, defects in expression of this enzyme lead to a fatal neurodegenerative disease, classical late-infantile neuronal ceroid lipofuscinosis. Similar enzymes have been found in the genomic sequences of several species, but neither systematic analyses of their distribution nor modeling of their structures have been previously attempted. SN - 1472-6807 UR - https://doi.org/10.1186/1472-6807-3-8 DO - 10.1186/1472-6807-3-8 ID - Wlodawer2003 ER -