Alignment of amino acid sequences of collagenases and chymotrypsins. The completely conserved sites (13) are marked by black boxes. The catalytic triad (His, Asp, Ser) is denoted by stars above the sequences. Amino acid sequences are shown for: CPC, collagenase from P. camtschaticus (Q8WR11); CUP, collagenase from Uca pugilator (Q27824); ChPV, chymotrypsin II from Pen. vannamei (P36178); CHL, collagenase from Hypoderma lineatum (P08897); ChBT, chymotrypsin A from B. taurus (P00788); and ChSG, chymotrypsin-like protease from Streptomyces griseus (P00776). Swiss-Prot database accession numbers are given in parentheses. The numbers above the sequences follow the established chymotrypsinogen numbering system.