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Figure 3 | BMC Structural Biology

Figure 3

From: Crystal structure of the Habc domain of neuronal syntaxin from the squid Loligo pealei reveals conformational plasticity at its C-terminus

Figure 3

Structure based sequence alignment of neuronal syntaxins Sequences from five animal phyla (SwissProt/ TrEMBL accession codes, L. pealei O46345, H. medicinalis O01390, D. melanogaster Q24547, C. elegans O16000, R. norvegicus P32851) were used. Secondary structure elements are indicated for neuronal syntaxin from L. pealei, above the sequence, based on the crystal structure of the Habc domain and the squid SNARE complex (pdb code 1L4A) [62]. Secondary structure element assignment for the rat homologue is based on the X-ray structure of syntaxin 1A in complex with nSec1 (pdb code 1DN1) [25] and is shown below the sequence, thus highlighting the different conformations that can be adopted by the SNARE motif. Identical residues are indicated by red background. Homologous residues are shown in red. Green triangles indicate syntaxin residues that interact with nSec1 in the closed conformation [25]. The region with divergent conformations at the C-terminus of the squid Habc domain is marked with a blue dashed line.

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