Table 1 Analysis of the Ramachandran plot and identity between template and models of NS3 protease variants. The accuracy of comparative modeling is related to the percentage of sequence identity on which the model is based, correlating with the relationship between the structural and sequence similarities of two proteins. High accuracy comparative models are based on >50% sequence identity to their templates. They tend to have ~1 Å r.m.s. error for the main-chain atoms, which is comparable to the accuracy of a medium-resolution NMR structure or a low-relosution X-ray structure. All structure models in the database were generated using alignments with more than 79% sequence identity, which generating models with high accuracy.
From: Molecular models of NS3 protease variants of the Hepatitis C virus
Genbank access code | Residue Range | Identity (%) | Region of the Ramachandran plot (%) | |||
|---|---|---|---|---|---|---|
Most Favorable | Additional Allowed | Generously Allowed | Disallowed | |||
AJ238800 | 1027 – 1657 | 95.0 | 94.9 | 5.1 | 0.0 | 0.0 |
AJ238799 | 1027 – 1657 | 95.7 | 95.1 | 4.6 | 0.2 | 0.2 |
AF139594 | 1028 – 1658 | 95.7 | 95.8 | 3.8 | 0.2 | 0.2 |
D17763 | 1033 – 1663 | 80.5 | 94.9 | 4.9 | 0.2 | 0.0 |
AF054247 | 1027 – 1657 | 94.0 | 95.0 | 4.8 | 0.2 | 0.0 |
AF054248 | 1027 – 1657 | 93.8 | 94.9 | 5.1 | 0.0 | 0.0 |
AF054249 | 1027 – 1657 | 93.8 | 95.2 | 4.8 | 0.0 | 0.0 |
D50409 | 1031 – 1661 | 80.3 | 95.1 | 4.9 | 0.0 | 0.0 |
D84262 | 1032 – 1662 | 84.2 | 95.0 | 5.0 | 0.0 | 0.0 |
D84263 | 1025 – 1665 | 83.1 | 95.2 | 4.8 | 0.0 | 0.0 |
D84264 | 1029 – 1659 | 83.9 | 95.2 | 4.8 | 0.0 | 0.0 |
D84265 | 1027 – 1657 | 82.5 | 94.9 | 5.1 | 0.0 | 0.0 |
D10749 | 1027 – 1657 | 90.5 | 94.9 | 5.1 | 0.0 | 0.0 |
D13558 | 1027 – 1657 | 94.1 | 94.8 | 5.2 | 0.0 | 0.0 |
D14853 | 1027 – 1657 | 88.8 | 95.3 | 4.7 | 0.0 | 0.0 |
D00944 | 1031 – 1661 | 79.8 | 95.1 | 4.9 | 0.0 | 0.0 |
D10988 | 1031 – 1661 | 79.7 | 95.1 | 4.9 | 0.0 | 0.0 |
AF046866 | 1033 – 1663 | 80.3 | 94.7 | 5.1 | 0.2 | 0.0 |
D49374 | 1035 – 1665 | 79.8 | 94.7 | 5.1 | 0.2 | 0.0 |
Y11604 | 1027 – 1657 | 84.7 | 95.4 | 4.6 | 0.0 | 0.0 |
Y13184 | 1028 – 1658 | 82.3 | 95.2 | 4.8 | 0.0 | 0.0 |
Y12083 | 1031 – 1661 | 81.9 | 94.6 | 5.2 | 0.0 | 0.2 |
U16362 | 1027 – 1657 | 92.6 | 95.2 | 4.6 | 0.2 | 0.0 |
U45476 | 1027 – 1657 | 94.7 | 94.9 | 5.1 | 0.0 | 0.0 |
AJ000009 | 1027 – 1657 | 95.2 | 95.1 | 4.9 | 0.0 | 0.0 |
M67463 | 1027 – 1657 | 89.6 | 94.9 | 4.9 | 0.2 | 0.0 |
D63822 | 1031 – 1661 | 79.2 | 95.2 | 4.8 | 0.0 | 0.0 |
D63821 | 1032 – 1662 | 79.1 | 94.7 | 5.1 | 0.2 | 0.0 |
D14484 | 1027 – 1657 | 94.3 | 95.8 | 4.2 | 0.0 | 0.0 |
D11168 | 1027 – 1657 | 94.9 | 95.0 | 5.0 | 0.0 | 0.0 |
D11355 | 1027 – 1657 | 94.6 | 95.0 | 5.0 | 0.0 | 0.0 |
D50480 | 1027 – 1657 | 93.5 | 95.0 | 5.0 | 0.0 | 0.0 |
D50481 | 1027 – 1657 | 94.6 | 95.4 | 4.6 | 0.0 | 0.0 |
D50482 | 1027 – 1657 | 94.7 | 95.5 | 4.3 | 0.2 | 0.0 |
D50483 | 1027 – 1657 | 93.6 | 95.2 | 4.8 | 0.0 | 0.0 |
D50485 | 1027 – 1657 | 94.3 | 95.6 | 4.4 | 0.0 | 0.0 |
D50484 | 1027 – 1657 | 94.1 | 95.3 | 4.7 | 0.0 | 0.0 |
D28917 | 1033 – 1663 | 80.5 | 95.2 | 4.6 | 0.2 | 0.0 |
D30613 | 1027 – 1657 | 93.8 | 95.4 | 4.6 | 0.0 | 0.0 |
D10934 | 1027 – 1657 | 95.2 | 95.3 | 4.7 | 0.0 | 0.0 |
AF207762 | 1027 – 1657 | 94.0 | 95.1 | 4.9 | 0.0 | 0.0 |