Figure 1

Sequence alignment of the transmembrane domains 1 and 2 of 28 human tetraspanins. Residues from select positions of the heptad motifs in TM1 and 2 are highlighted (see text for details). Also highlighted are polar residues and cysteines. Consensus residue types are shown by the color scheme indicated. Boxed residues reflect correlated substitutions for position pairs 22–74 and 25–70 (details are in the text). The numbers refer to CD9 sequence.