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Table 2 Published mutant data and predicted V50 values.

From: Computational identification of residues that modulate voltage sensitivity of voltage-gated potassium channels

Ala scan (Kv2.1)

Published V50 (mV)

Predicted V50 (mV)

Wild type (mV)

L97A

0.6

-7.23

-4.9

*I100A

-7.3

-7.23

-4.9

L117A

-1.6

-7.23

-4.9

*V125A

-4.6

-7.23

-4.9

L135A

1.5

-7.23

-4.9

A154Y

7

27.5

-4.9

MAE

7.5

  1. The V50 predictions for a set of published alanine scanning mutants are compared to the published measured V50 values. The residues marked with * are residues in which an alanine exists at this position in at least one of the channels in the training dataset.