Table 2 Comparison of predicted and experimental changes in aggregation for Aβ variants.
From: Prediction of "hot spots" of aggregation in disease-linked polypeptides
Mutation | ΔAP* | Observed aggregation‡ |
|---|---|---|
A21G | -1.22 | - |
E22G | +2.14 | + |
E22Q | +0.44 | + |
F19P | -5.09 | - |
F19T | -4.73 | - |
I31L | -1.07 | - |
I32L | -1.07 | - |
I41G | -5.76 | - |
I41A | -4.52 | - |
I41L | -1.075 | - |
A42G | -1.21 | - |
A42V | +3.95 | + |
Δ1–4 | +4.82 | + |
Δ1–9 | +21.86 | + |
Δ40–42 | -8.34 | - |
Δ41–42 | -4.26 | - |
V12E+V18E+M35T+I41N | -18.96 | - |
F19S+L34P | -9.18 | - |