TY - JOUR AU - Kozbial, Piotr Z. AU - Mushegian, Arcady R. PY - 2005 DA - 2005/10/14 TI - Natural history of S-adenosylmethionine-binding proteins JO - BMC Structural Biology SP - 19 VL - 5 IS - 1 AB - S-adenosylmethionine is a source of diverse chemical groups used in biosynthesis and modification of virtually every class of biomolecules. The most notable reaction requiring S-adenosylmethionine, transfer of methyl group, is performed by a large class of enzymes, S-adenosylmethionine-dependent methyltransferases, which have been the focus of considerable structure-function studies. Evolutionary trajectories of these enzymes, and especially of other classes of S-adenosylmethionine-binding proteins, nevertheless, remain poorly understood. We addressed this issue by computational comparison of sequences and structures of various S-adenosylmethionine-binding proteins. SN - 1472-6807 UR - https://doi.org/10.1186/1472-6807-5-19 DO - 10.1186/1472-6807-5-19 ID - Kozbial2005 ER -