Figure 2

Glycerate kinase structures. a) Neisseria meningitides glycerate kinase (PDB|1to6), a representative of first glycerate kinase family (previously Group 15). Highly conserved amino acids with side chains pointing into the presumed active site include 6 residues from the Rossmann-like domain (1 – Asp8, 2 – Lys11, 3 – Asp43, 6 – Glu286, 7 – Asp290, and 8 – Lys297) and 2 residues from the inserted domain (4 – Asp191 and 5 – Gln209). Glycine rich loops are shown in magenta. Sulfates are shown in ball-and-stick representation. b) Thermotoga maritima putative glycerate kinase (PDB|1o0u), a member of the second glycerate kinase family (previously Group 16, now Group 10). Highly conserved amino acids with side chains pointing into the presumed active site include 2 residues from the Rossmann-like domain (1 – Lys47 and 2 – Asp189) and 4 residues from the C-terminal domain (3 – Glu312, 4 – Arg325, 5 – Asp351, and 6 – Asn407). The glycine rich loop is shown in magenta.