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Table 1 Classification of kinase activities by family and fold group, part 1.

From: A comprehensive update of the sequence and structure classification of kinases

Group

Family and PFAM/COG members

Kinase Activity (E.C.)

Representative PDB or gi

Group 1: protein S/T-Y kinase/ atypical protein kinase/ lipid kinase/ ATP-grasp 23124 sequences

protein S/T-Y kinase/ atypical protein kinase: COG0478, COG2112, PF00069, PF00454, PF01163, PF01633 22074 sequences

2.7.1.32 Choline kinase (*)

PDB: 1cdk

  

2.7.1.37 Protein kinase

 
  

2.7.1.38 Phosphorylase kinase

 
  

2.7.1.39 Homoserine kinase

 
  

2.7.1.67 1-phosphatidylinositol 4-kinase

 
  

2.7.1.72 Streptomycin 6-kinase

 
  

2.7.1.82 Ethanolamine kinase

 
  

2.7.1.87 Streptomycin 3"-kinase

 
  

2.7.1.95 Kanamycin kinase

 
  

2.7.1.100 5-methylthioribose kinase

 
  

2.7.1.103 Viomycin kinase

 
  

2.7.1.109 [Hydroxymethylglutaryl-CoA reductase (NADPH 2 )] kinase

 
  

2.7.1.112 Protein-tyrosine kinase

 
  

2.7.1.116 [Isocitrate dehydrogenase (NADP+)] kinase

 
  

2.7.1.117 [Myosin light-chain] kinase

 
  

2.7.1.119 Hygromycin-B kinase

 
  

2.7.1.123 Calcium/calmodulin-dependent protein kinase

 
  

2.7.1.125 Rhodopsin kinase

 
  

2.7.1.126 [Beta-adrenergic-receptor] kinase (*)

 
  

2.7.1.129 [Myosin heavy-chain] kinase

 
  

2.7.1.135 [Tau protein] kinase (*)

 
  

2.7.1.136 Macrolide 2'-kinase

 
  

2.7.1.137 1-phosphatidylinositol 3-kinase

 
  

2.7.1.141 [RNA-polymerase]-subunit kinase

 
  

2.7.1.153 Phosphatidylinositol-4,5-bisphosphate 3-kinase

 
  

2.7.1.154 Phosphatidylinositol-4-phosphate 3-kinase

 
 

lipid kinase: PF01504 321 sequences

2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase

PDB: 1bo1

  

2.7.1.127 1D-myo-inositol-trisphosphate 3-kinase (*)

 
  

2.7.1.140 Inositol-tetrakisphosphate 5-kinase

 
  

2.7.1.149 1-phosphatidylinositol 5-phosphate 4-kinase

 
  

2.7.1.150 1-phosphatidylinositol 3-phosphate 5-kinase

 
  

2.7.1.151 Inositol-polyphosphate multikinase

 
  

2.7.4.21 Inositol-hexakisphosphate kinase

 
 

ATP-grasp: PF01326 729 sequences

2.7.1.134 Inositol-tetrakisphosphate 1-kinase

PDB: 1dik

  

2.7.9.1 Pyruvate, phosphate dikinase

 
  

2.7.9.2 Pyruvate, water dikinase

 

Group 2: Rossmann-like 17071 sequences

P-loop kinases: COG0645, COG1618, COG1663, COG1936, COG2019, PF00265, PF00406, PF00485, PF00625, PF00693, PF01121, PF01202, PF01583, PF01591, PF01712, PF02223, PF02224, PF02283 7732 sequences

2.7.1.12 Gluconokinase (*)

PDB: 1qf9

  

2.7.1.19 Phosphoribulokinase

 
  

2.7.1.21 Thymidine kinase

 
  

2.7.1.22 Ribosylnicotinamide kinase

 
  

2.7.1.24 Dephospho-CoA kinase

 
  

2.7.1.25 Adenylylsulfate kinase

 
  

2.7.1.33 Pantothenate kinase

 
  

2.7.1.37 Protein kinase (bacterial)

 
  

2.7.1.48 Uridine kinase (*)

 
  

2.7.1.71 Shikimate kinase

 
  

2.7.1.74 Deoxycytidine kinase (*)

 
  

2.7.1.76 Deoxyadenosine kinase

 
  

2.7.1.78 Polynucleotide 5'-hydroxyl-kinase (*)

 
  

2.7.1.105 6-phosphofructo-2-kinase

 
  

2.7.1.113 Deoxyguanosine kinase

 
  

2.7.1.130 Tetraacyldisaccharide 4'-kinase

 
  

2.7.1.145 Deoxynucleoside kinase (*)

 
  

2.7.1.156 Adenosylcobinamide kinase

 
  

2.7.4.1 Polyphosphate kinase

 
  

2.7.4.2 Phosphomevalonate kinase

 
  

2.7.4.3 Adenylate kinase

 
  

2.7.4.4 Nucleoside-phosphate kinase

 
  

2.7.4.8 Guanylate kinase

 
  

2.7.4.9 Thymidylate kinase

 
  

2.7.4.10 Nucleoside-triphosphate – adenylate kinase

 
  

2.7.4.13 (Deoxy)nucleoside-phosphate kinase

 
  

2.7.4.14 Cytidylate kinase

 
  

2.7.4.- Uridylate kinase

 
 

phosphoenolpyruvate carboxykinase: COG1493, PF01293, PF00821 815 sequences

2.7.1.37 Protein kinase (HPr kinase/phosphatase)

PDB: 1aq2

  

4.1.1.32 Phosphoenolpyruvate carboxykinase (GTP)

 
  

4.1.1.49 Phosphoenolpyruvate carboxykinase (ATP)

 
 

phosphoglycerate kinase: PF00162 1351 sequences

2.7.2.3 Phosphoglycerate kinase

PDB: 13pk

  

2.7.2.10 Phosphoglycerate kinase (GTP)

 
 

aspartokinase: PF00696 2171 sequences

2.7.2.2 Carbamate kinase

PDB: 1b7b

  

2.7.2.4 Aspartate kinase

 
  

2.7.2.8 Acetylglutamate kinase (*)

 
  

2.7.2.11 Glutamate 5-kinase

 
  

2.7.4.- Uridylate kinase

 
 

phosphofructokinase-like: PF00365, PF00781, PF01219, PF01513 1998 sequences

2.7.1.11 6-phosphofructokinase

PDB: 4pfk

  

2.7.1.23 NAD(+) kinase (*)

 
  

2.7.1.56 1-phosphofructokinase

 
  

2.7.1.90 Diphosphate – fructose-6-phosphate 1- phosphotransferase (*)

 
  

2.7.1.91 Sphinganine kinase

 
  

2.7.1.107 Diacylglycerol kinase

 
  

2.7.1.138 Ceramide kinase

 
 

ribokinase-like: PF00294, PF01256, PF02110 2722 sequences

2.7.1.2 Glucokinase

PDB: 1rkd

  

2.7.1.3 Ketohexokinase

 
  

2.7.1.4 Fructokinase

 
  

2.7.1.11 6-phosphofructokinase

 
  

2.7.1.15 Ribokinase

 
  

2.7.1.20 Adenosine kinase

 
  

2.7.1.35 Pyridoxal kinase (*)

 
  

2.7.1.45 2-dehydro-3-deoxygluconokinase

 
  

2.7.1.49 Hydroxymethylpyrimidine kinase

 
  

2.7.1.50 Hydroxyethylthiazole kinase

 
  

2.7.1.56 1-phosphofructokinase

 
  

2.7.1.73 Inosine kinase

 
  

2.7.1.92 5-dehydro-2-deoxygluconokinase

 
  

2.7.1.144 Tagatose-6-phosphate kinase

 
  

2.7.1.146 ADP-dependent phosphofructokinase

 
  

2.7.1.147 ADP-dependent glucokinase

 
  

2.7.4.7 Phosphomethylpyrimidine kinase (*)

 
 

thiamin pyrophosphokinase 175 sequences

2.7.6.2 Thiamin pyrophosphokinase

PDB: 1ig0

 

glycerate kinase (previously Group 15) 107 sequences

2.7.1.31 Glycerate kinase (*)

PDB: 1to6