Figure 5

Analysis of the protein surface of aaTHEP1. Shown are surface and cartoon representations of aaTHEP1 in identical orientations. Conserved residues are colour coded as in Figure 1 (top). Positive electrostatic surface potentials as determined by Swiss pdb-viewer [43] are depicted blue, negative potentials in red (middle). Shown are two views related by a 180° rotation around the y-axis. In the magnified part of the active cleft, a GTP and ATP molecule can be seen. The positions of those nucleotides were constructed by superimposing the structures of the H-Ras P21 protein complexed with GppNHp (pdb-code: 5P21, [12]) and RecA complexed with ADP (pdb-code: 1MO3, [13]), respectively.