NOE's and RMSD's broken down by residue. (A) Distribution of NOE's as a function of residue. Long-range (|i-j|> = 5) – lilac bars; medium-range (1<|i-j|<5) – green bars; short-range (|i-j|< = 1) – yellow bars. NOE's are counted twice – once for each residue involved. (B) RMSD across the family of 25 structures, as a function of residue. Regions of secondary structure correlate well with low RMSD and large numbers of long-range NOE's.