Figure 1

The interface residues shown against the sequence of c-AMP dependent protein kinase in complex with H7 protein kinase inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (PDB file, 1ydr) [24]. There are two patches and the residues belonging to them are shown in orange and magenta (in decreasing patch size). Core and rim residues are distinguished by upper and lower-case letters, respectively. An α-helix is represented by red undulation and a β-strand by blue arrow.