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Table 4 Summary of TM helices for which LIPS failed to correctly predict the lipid-exposed surfaces. Rationalization of the failure is listed for some helices.

From: Prediction of transmembrane helix orientation in polytopic membrane proteins

Protein

Helix

Rationalization

1IWG

TM2

(N/C)* LIPS offers a second best choice of lipid-exposed helical face

 

TM8

Regular helical structure is broken around A889 and A890. LIPS offers a second best choice

1KQF

TM1

Cardiolipin binding

1M3X

TM11

Cardiolipin binding

1OCR

TM18

(N/C) LIPS offers a second best choice

1PV6

TM4

Regular helical structure is broken around N119 by P123

1PW4

TM12

(N/C) LIPS offers a second best choice

1Q90

TM2

Heme interaction

  1. * N/C: Not clear.