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Figure 3 | BMC Structural Biology

Figure 3

From: A general method for the unbiased improvement of solution NMR structures by the use of related X-Ray data, the AUREMOL-ISIC algorithm

Figure 3

Improvement of the solution structure of RalGDS-RBD by an X-ray structure of the same molecule in complex with Ras. Upper Panel: (A) Newly calculated low resolution NMR structural bundle of RalGDS-RBD. (B) Input X-ray structure of RalGDS obtained in complex with Ras. Lower Panel: (C) 10 final refined structures of RalGDS-RBD without refinement in explicit solvent. (D) Reference NMR structure created from a full set of experimental restraints (25 h-bonds, 104 Φ and Ψ dihedral angles, and 1550 NOEs).

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