Table 1 Gibbs free energies and specific volumesa
From: Observation of intermediate states of the human prion protein by high pressure NMR spectroscopy
Domain | Transition | K 0 | ΔG0 [kJ mol-1] | ΔV0 [ml mol-1] | ΔV0 [nm3] |
|---|---|---|---|---|---|
hu PrP(23–230) | |||||
amino acid 23–120 | N1 ▶ N2 | 0.292 | 3.0 ± 1.1 | -63 ± 11 | -0.10 ± 0.02 |
N â–¶ I | n. d. | n. d. | n. d. | n. d. | |
amino acid 121–230 | N1 ▶ N2 | 0.300 | 2.9 ± 1.3 | -79 ± 15 | -0.13 ± 0.02 |
N â–¶ I | n. d. | n. d. | n. d. | n. d. | |
hu PrP(121–230) | |||||
amino acid 121–230 | N1 ▶ N2 | 0.292 | 3.0 ± 1.4 | -86 ± 17 | -0.14 ± 0.03 |
N ▶ I1 | 0.012 | 10.8 ± 1.9 | -66 ± 26 | -0.11 ± 0.04 | |
N ▶ I2 | 0.0005 | 18.6 ± 2.9 | -125 ± 32 | -0.21 ± 0.05 |