Left: Hen egg-white lysozyme with its ligand Tri-N-Acetylchitotriose (PDB 1hel). The ligand binds in a deep pocket and all algorithms correctly predict the binding site. red: LIGSITEcsc, blue: LIGSITE, cyan: PASS, yellow: SURFNET, orange: CAST. Right: Hexameric insulin with its ligand methylparaben (PDB 6ins). The binding site of the ligand is unusually flat and therefore none of the methods detects it correctly.