TY - JOUR AU - Argiriadi, Maria A. AU - Goedken, Eric R. AU - Bruck, Irina AU - O'Donnell, Mike AU - Kuriyan, John PY - 2006 DA - 2006/01/10 TI - Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium JO - BMC Structural Biology SP - 2 VL - 6 IS - 1 AB - Sliding DNA clamps are processivity factors that are required for efficient DNA replication. DNA polymerases maintain proximity to nucleic acid templates by interacting with sliding clamps that encircle DNA and thereby link the polymerase enzyme to the DNA substrate. Although the structures of sliding clamps from Gram-negative bacteria (E. coli), eukaryotes, archaea, and T4-like bacteriophages are well-known, the structure of a sliding clamp from Gram-positive bacteria has not been reported previously. SN - 1472-6807 UR - https://doi.org/10.1186/1472-6807-6-2 DO - 10.1186/1472-6807-6-2 ID - Argiriadi2006 ER -