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Figure 1 | BMC Structural Biology

Figure 1

From: Autoinsertion of soluble oligomers of Alzheimer's Aβ(1–42) peptide into cholesterol-containing membranes is accompanied by relocation of the sterol towards the bilayer surface

Figure 1

Insertion of Aβ(1–42) oligomers into lipid monolayers. Panel a illustrates spontaneous insertion of oligomeric but not monomeric Aβ(1–42) into a monolayer containing 7:3 (mol/mol) POPC:Chol compresssed to a lateral surface pressure of 15 mN/m (representative of 6 similar experiments). Panel b shows exclusion of peptide oligomers at a surface pressure of ~20 mN/m in binary lipid mixtures containing POPE/POPS or POPC/Chol. Note the lack of insertion in POPC monolayers without Chol. Panel c shows the molecular insertion areas of the peptide oligomer. All the points are means of 2 experiments, and the molar concentrations of the peptide refer to the initial monomer concentrations.

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