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Figure 1 | BMC Structural Biology

Figure 1

From: Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics

Figure 1

Global structure of Asf1N bound to H3α3. (A) Stereo view of Asf1N (orange) bound to the H3α3 helix (blue). β-strands are labeled as per the nomenclature for switched-type Ig-like folds. A section of an electron density omit-map generated in the absence of the histone helix is shown contoured at 2.5σ. (B) Front and side views superposing known Asf1 structures. α-carbon atoms of Asf1 from the current structure (green), the non-histone bound yeast Asf1 (PDB ID 1ROC, blue), and the human Asf1a (PDB ID 1TEY, red) were used for the alignment and shown as a-carbon representations. Arrows indicate the loops connecting b-strands c and c' (loop 1), and connecting b-strands e and f (loop 2), which both rotate forward upon binding H3α3.

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