Average performance of the method on a fold nonredundant enzyme dataset. All folds in ASTRAL 40 v1.65 with annotations in the Catalytic Site Atlas (CSA) were collected, and from each a random member was selected. Then each representative was run against the method using the database specified in the legend, with the HMMer results excluded. The same set was run against ASTRAL 95 v1.67, if the domain was not found in v1.67, another random member of that fold was chosen, if the fold was not found in v1.67, it was excluded. The sensitivity and precision were measured as (true positives/total positives) and (true positives/total hits), respectively. EC.3 is the first three numbers of the EC number and SCOP SF is the first three numbers of the SCOP ID (superfamily).