Table 3 Variation within functional categories in minimal organisms. Which functional categories show the most variation in fold usage between minimal organisms? The data are calculated as in Table 2, but ignore data from E. coli. The structure-based variation when E coli data are included (from Table 2) is provided for comparison.
Category | Average # of Proteins | Fold-based variation (CVstructure) | Fold-based variation, including E. coli | Sequence-based variation(CVsequence) | Fold-based Rank/Sequence-based Rank |
|---|---|---|---|---|---|
Protein synthesis | 95.2 | 0.108 | 0.141 | 0.039 | 1/1 |
Transcription | 17.6 | 0.200 | 0.286 | 0.199 | 2/3 |
All Proteins | 606.8 | 0.210 | 1.061 | 0.178 | 3/2 |
DNA metabolism | 33.0 | 0.314 | 0.586 | 0.328 | 4/6 |
Fatty acid and phospholipid metabolism | 12.0 | 0.358 | 1.328 | 0.486 | 5/9 |
Regulatory functions | 7.2 | 0.402 | 1.427 | 0.465 | 6/8 |
Purines, pyrimidines, nucleosides, and nucleotides | 28.8 | 0.405 | 0.462 | 0.284 | 7/4 |
Protein fate | 34.6 | 0.560 | 0.731 | 0.303 | 8/5 |
Unknown function | 27.8 | 0.776 | 1.659 | 0.555 | 9/12 |
Transport and binding proteins | 27.4 | 0.796 | 1.809 | 0.574 | 10/13 |
Energy metabolism | 59.4 | 0.799 | 1.276 | 0.454 | 11/7 |
Biosynthesis of cofactors, prosthetic groups, and carriers | 38.6 | 0.816 | 1.332 | 0.666 | 12/15 |
Amino acid biosynthesis | 29.0 | 0.844 | 0.935 | 0.782 | 13/17 |
Cellular processes | 29.8 | 0.853 | 1.364 | 0.636 | 14/14 |
Cell envelope | 45.8 | 0.893 | 1.099 | 0.506 | 15/10 |
Central intermediary metabolism | 15.4 | 0.952 | 1.228 | 0.552 | 16/11 |
Unclassified | 30.0 | 1.006 | 2.020 | 0.749 | 17/16 |
Hypothetical proteins | 70.6 | 1.125 | 1.984 | 0.871 | 18/18 |