Figure 6From: Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleftTyr66 φ/ψ distributions in the three simulations. Data are taken at 0.02-ns intervals and span the full lengths of the simulations, which were 10 ns for 1AYD:N-SH2 and 2SHP:N-SH2, and 5 ns for 2SHP:SHP-2.Back to article page