Figure 9
Crystallographic conformations of Asp40, Lys55, Gln57, and Tyr66. A) Conformation in the isolated N-SH2 domain [PDB:1AYD]. B) Conformation in the full SHP-2 protein [PDB:2SHP]. π-stacking is represented by green dashes and hydrogen-bond/salt-bridge interactions are circled in pink. The Cε and N atoms of the Lys55 sidechain are missing in 1AYD.