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Figure 10 | BMC Structural Biology

Figure 10

From: The high-resolution NMR structure of the R21A Spc-SH3:P41 complex: Understanding the determinants of binding affinity by comparison with Abl-SH3

Figure 10

Involvement of water in the SH3:P41 binding interface. The five water molecules (green spheres) that were proposed to contribute to the highly favorable binding enthalpy in the Abl-SH3:P41 complex (left panel) were modeled into the R21A Spc-SH3:P41 structure (right panel) by direct superposition of the two complexes. Waters W1082 and W1105 (labeled in the Abl-SH3:P41 complex) are similarly buried in the two complexes, while the remaining three waters (highlighted by a white circle) are exposed in the R21A Spc-SH3:P41 complex and likely not anymore present in the binding interface.

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BMC Structural Biology

ISSN: 1472-6807

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