Figure 1

Sensitivity curves for the three best-performing measures. The fraction of correctly ranked homologous VAST neighbors (true positives, sensitivity) is plotted against the fraction of incorrectly ranked homologous VAST neighbors for similarity measures yielding the best performance: HCS (green)), LHM (red) and GSAS (cyan). True and false positive (error) rate values at each cutoff of similarity measures were averaged over protein families from the overall test set (152 families).