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Table 2 Residues in the helix-helix interfaces of aquaporin crystal structures. Residue pairs that occur at the helix-helix interface in the six high-resolution aquaporin crystal structures.

From: Homology modeling of major intrinsic proteins in rice, maize and Arabidopsis: comparative analysis of transmembrane helix association and aromatic/arginine selectivity filters

Helix Pairs Residues from the crystal structuresa <dist.>b(Å)
TM1...TM2 S28...F58, G25...W48, G19...F43, T55...F81,G27...F48, G22...F62 4.86
TM1...TM3 M21...Q103, T18...Q93, T12...Q88, T48...Q126, T20...Q93, T15...Q107 5.74
  F18...G106, F15...G96, C9...G91, F45...G129, F17...G9 6, F12...G110 4.55
  I25...A107, I22...A97, V16...G92 L52...A130, V24...A97, V19...A111 5.70
  I25...A110, I22...A100, V16...A95, L52...G133, V24...G100, V19...G114 5.52
TM4...TM6 T148...P218, T156...P240, S142...P212, T172...P249, T138...P208, T154...P229 5.29
  A157...Y229, A165...Y251, G151...Y223, S181...H260, A147...Y219, G163...Y240 7.73
  L141/I145...G217, F149/M153...G239, L135/L139...V211, L165/I169...G248, T131/I135...G207, M147/V151...G228 5.31
  I145/L149...G221, M153/A157...G243, L139/A143...G215, I169/F173...G252, I135/L139...G211, V151/F155...G232 4.35
  L149/V152...A225, A157/M160...G247, A143/L146...G219, F173/V176...A256, L139/V142...G215, F155/M158...A236 5.17
  V152...A222, M160...A244, L146...G216, V176...A253, V142...A212, M158...A233 5.51
TM2...TM5 S55...L183, S45...A192, A40...L175, A78...L211, A45...L173, G59...T188 5.91
  G59...G175,G59...G184,G44...G167, G82...G203,G49...G165,G63...G180 4.31
LB...TM4 G84...V152, A74...M160, G69...L146, G107...V176, A74...V142, G88...M158 6.96
LB...TM6 A80...A222,A70...A244,A65...G216, A103...A253,A70...A212,A84...A233 5.75
LE...TM3 G200...A107,G209...A97,A192...G92, G228...A130,A190...A97,G205...A111 4.89
LE...TM6 S198...F214, D207...P236, S190...F208, S226...F245,S188...Y204, T203...Y225 6.52
  1. a Residue pairs are given respectively for the crystal structures 1J4N, 1FX8, 1RC2, 1Z98, 2B6O and 2F2B. For each residue given for 1J4N, the equivalent residues from the other crystal structures were obtained from structure-based sequence alignment (see Additional files 1 to 8). For example, the equivalent residue pairs for (S28, F58) in 1J4N are (G25, W48) in 1FX8, (G19, F43) in 1RC2, (T55, F81) in 1Z98, (G27, F48) in 2B6O and (G22, F62) in 2F2B. Small residues (Gly/Ala/Ser/Thr) are shown in bold. b Average Cα...Cα distances calculated for residue pairs from all the six crystal structures are given.