Table 2 Residues in the helix-helix interfaces of aquaporin crystal structures. Residue pairs that occur at the helix-helix interface in the six high-resolution aquaporin crystal structures.
Helix Pairs | Residues from the crystal structuresa | <dist.>b(Ã…) |
|---|---|---|
TM1...TM2 | S28...F58, G25...W48, G19...F43, T55...F81,G27...F48, G22...F62 | 4.86 |
TM1...TM3 | M21...Q103, T18...Q93, T12...Q88, T48...Q126, T20...Q93, T15...Q107 | 5.74 |
| Â | F18...G106, F15...G96, C9...G91, F45...G129, F17...G9 6, F12...G110 | 4.55 |
| Â | I25...A107, I22...A97, V16...G92 L52...A130, V24...A97, V19...A111 | 5.70 |
| Â | I25...A110, I22...A100, V16...A95, L52...G133, V24...G100, V19...G114 | 5.52 |
TM4...TM6 | T148...P218, T156...P240, S142...P212, T172...P249, T138...P208, T154...P229 | 5.29 |
| Â | A157...Y229, A165...Y251, G151...Y223, S181...H260, A147...Y219, G163...Y240 | 7.73 |
| Â | L141/I145...G217, F149/M153...G239, L135/L139...V211, L165/I169...G248, T131/I135...G207, M147/V151...G228 | 5.31 |
| Â | I145/L149...G221, M153/A157...G243, L139/A143...G215, I169/F173...G252, I135/L139...G211, V151/F155...G232 | 4.35 |
| Â | L149/V152...A225, A157/M160...G247, A143/L146...G219, F173/V176...A256, L139/V142...G215, F155/M158...A236 | 5.17 |
| Â | V152...A222, M160...A244, L146...G216, V176...A253, V142...A212, M158...A233 | 5.51 |
TM2...TM5 | S55...L183, S45...A192, A40...L175, A78...L211, A45...L173, G59...T188 | 5.91 |
| Â | G59...G175,G59...G184,G44...G167, G82...G203,G49...G165,G63...G180 | 4.31 |
LB...TM4 | G84...V152, A74...M160, G69...L146, G107...V176, A74...V142, G88...M158 | 6.96 |
LB...TM6 | A80...A222,A70...A244,A65...G216, A103...A253,A70...A212,A84...A233 | 5.75 |
LE...TM3 | G200...A107,G209...A97,A192...G92, G228...A130,A190...A97,G205...A111 | 4.89 |
LE...TM6 | S198...F214, D207...P236, S190...F208, S226...F245,S188...Y204, T203...Y225 | 6.52 |