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Figure 1 | BMC Structural Biology

Figure 1

From: Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics

Figure 1

Disulfide isomers of BuIA. (A) A schematic representation of the ribbon, globular and beads disulfide connectivities of BuIA, a conotoxin having the unique 4/4 loop spacing. (B) HPLC traces of ribbon and globular BuIA. Analytical HPLC was carried out using a C18 Phenomenex analytical column (250 × 4.6 mm) with 90% acetonitrile and 0.043% trifluroacetic acid as the eluting solvent B and 1% B per minute as the gradient. Ribbon BuIA elutes earlier than the globular form but has a slightly broadened peak under the conditions utilized.

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