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Table 1 Sequences and activities of selected α-conotoxins

From: Structure of α-conotoxin BuIA: influences of disulfide connectivity on structural dynamics

Name

Spacing a

Sequence

Receptor b

Species

Ref.

GI

3/5

ECC-NPAC GRHYSC*

M α1β1γδ

C. geographus

[13]

ImI

4/3

GCC SDPRC AWRC*

N α7

C. imperialis

[41]

BuIA

4/4

GCC STPPC AVLYC*

N α6/α3 β4/β2

C. bullatus

[16]

AuIB

4/6

GCC SYPPC FATNPDC*

N α3 β4

C. aulicus

[42]

PnIA

4/7

GCC SLPPC AANNPDYC*

N α3 β2

C. pennaceus

[43]

Cys

I

II

III

IV

 
  1. anumber of residues between the second and third, and the third and fourth cysteines
  2. bM, muscle nAChR; N, neuronal nAChR
  3. * C terminal amide
  4. Sequences, in one letter code, are aligned using the conserved cysteines forming disulfide bonds, shown in bold.