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Figure 5 | BMC Structural Biology

Figure 5

From: The crystal structure of Escherichia coli TdcF, a member of the highly conserved YjgF/YER057c/UK114 family

Figure 5

Comparisons of the TdcF ligand-binding pocket. Stereoviews depicting comparisons of the TdcF ligand-binding pocket. (A) shows a superposition of all the states displayed in Figures 3 and 4, where: grey = empty site; blue = ethylene glycol-bound (the ethylene glycol itself is mainly occluded by other ligands in this view); yellow = serine-bound; red = 2-ketobutyrate-bound; green = propionate-bound. (B) shows a superposition of the ligand-binding site from TdcF with 2-ketobutyrate bound in red, onto the site from hp14.5 with a benzoic acid molecule bound in blue (primary site only)(PDB accession code 1ONI), and the equivalent site in YjgF in yellow (PDB accession code 1QU9). In the latter, two conformers are seen for Cys-107, the major one being covalently modified and protruding into the ligand-binding pocket. Throughout, the view is identical to that seen in Figures 3 and 4. Figure generated using PyMOL [31].

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