Figure 4

Comparison of theoretical root mean square fluctuations of (A) unbound-LAO (PDB 2lao) and (B) 36–65 Fab, antibody- heavy chain (PDB 2a6j) with the experimentally known conformational changes (ΔR = R_o - R_c). The solid curves represent the experimental changes whereas the dashed curves are obtained from the theory. Note that the theoretical curve is scaled to have the same area under the curve with the experimental one. The theoretical fluctuations that are driven by the second and third global modes are shown for LAO and the antibody fragment, respectively.