Skip to main content
Figure 2 | BMC Structural Biology

Figure 2

From: The NMR structure of the murine DLC2 SAM domain reveals a variant fold that is similar to a four-helix bundle

Figure 2

A comparison of DLC2-SAM domain and other SAM domains. (a) A representative structure of the DLC2-SAM domain in ribbon form and as ensemble of the 10 lowest energy solutions. A short helix H3 (cyan) typically observed in SAM domains such as (b) S. cerevisiae Ste50 [PDB: 1Z1V] is absent in the DLC2-SAM domain. (c) Sequence alignment of murine DLC2 with SAM domains known to participate in protein-protein interactions. Listed below DLC2 are SAM domains from Drosophila Polyhomeotic (Ph), Drosophila Sex-Comb-on-Midleg (Scm), S. cerevisiae Ste11 and Ste50. Hydrophobic amino acids that contribute to the hydrophobic core are highlighted.

Back to article page

BMC Structural Biology

ISSN: 1472-6807

Contact us