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Table 2 Estimated inhibition constants of GSTs by conventional anthelmintics

From: X-ray structures of Na-GST-1 and Na-GST-2 two glutathione s-transferase from the human hookworm Necator americanus

Enzyme

Na-GST-1

Na-GST-2

As-GST-1*

Inhibitor

IC50 (μM)

IC50 (μM)

IC50 (μM)

Albendazole

87

68

520.0

Chlorotriphenyltin

22

0.7

0.3

Praziquantel

(>20,000)**

3300

--

  1. * Data from As-GST-1 is from reference [42]
  2. ** This was the maximum concentration tried due to solubility issues.