Calculated membrane binding modes for Radixin-FERM domains with lipid ligand PI(4,5)P
(A) and CALM-ANTH with lipid ligand PI(4,5)P
(B). The backbone of two S-type domains and the specific lipid ligands are shown in ribbon and stick model, respectively. Cationic residues involved in ligand and membrane interactions are colored blue. Hydrocarbon core boundary at the cytoplasmic side is indicated by blue dots. The layer of lipid phosphates ("P") is shown by gold dots (at 5 Å outside the hydrocarbon boundary). The center of membrane is indicated by grey dots (at 15 Å inside the boundary).