Skip to main content

Table 2 Predicted penetration depths (D) and binding energies (ΔG calc ) of peripheral proteins and peptides, whose overall orientations or penetration depths in the lipid bilayer have been experimentally evaluated.

From: The role of hydrophobic interactions in positioning of peripheral proteins in membranes

Protein PDB id ΔG calc (kcal/mol) D(Å) Methoda References
Lipid clamps
C1 domain of protein kinase Cγ 1tbn -2.3 7.5 NMR [114]
Annexin 24 1dk5 -1.2 1.8 FL [115]
Blood coagulation factor VIIa 1dan -5.7 4.8 FL [116]
Seminal plasma protein 1h8p -12.3 9.2 EPR [117]
Other proteins
Cardiotoxin III 1h0j -13.1 6.5 FTIR [118]
Cytotoxin 1 1tgx -12.4 6.8 FLq [119]
Cardiotoxin II 1ffj -18.1 8.7 NMR [120]
Sapecin 1l4v -6.6 6.1 NMR [121]
Cytochrome c 1hrc -2.0 1.9 SL, NMR [122, 123]
Coagulation factor IXa 1pfx -3.8 3.2 FL [124]
Coagulation factor XIV 1lqv -4.9 3.5 FL [125]
Peptides
Alamethicin 1amt -23.7 28.1 NMR, SL [44–46]
Zervamicin IIb 1ih9 -14.3 9.9 FL [47]
Antiamoebin I 1joh -16.4 14.4 FL [47]
Magainin 2mag -14.5 10.1 NMR, FL [126, 127]
Nisin 1wco -4.0 8.8 NMR [128]
Neuropeptide Y 1icy -9.4 9.4 SL [129]
Mersacidin 1mqz -4.9 3.5 NMR [130]
  1. aAs in Table 1; FTIR – ATR FTIR spectroscopy.