Skip to main content

Table 7 Comparison of calculated energies (ΔG calc , kcal/mol), predicted penetration depths (D, Å) and protein tilts with respect to the membrane normal (τ, °) for alternative conformations of membrane-associated loops of different peripheral proteins.

From: The role of hydrophobic interactions in positioning of peripheral proteins in membranes

Protein

Category

Conformation 1a

Conformation 2a

  

PDB id

Δ G calc

D

Ï„

PDB id

Δ G calc

D

Ï„

Signal peptidase

A.1

1kn9

-4.5

4.5

83

1t7d

-5.9

3.7

66

Cytochrome P450 2b4

A.1

1po5

-6.9

9.7

39

2bdm

-18.2

10.5

45

Cytochrome P450 2c5

A.1

1nr6

-11.6

12.5

54

1dt6

-8.4

7.5

17

Cytochrome P450 2c9

A.1

1og5

-13.6

7.5

74

1r9o

-10.7

7.5

57

Cytochrome P450 3a4

A.1

1tqn

-20.7

10.2

61

1w0f

-15.2

6.2

68

Bile-salt activated lipase

C.1

1aql

-9.7

6.0

80

1akn

-6.6

5.7

67

Triacylglycerol lipase

C.1

1tib

-3.3

1.9

42

1dt5

-4.8

2.9

84

Lipase/colipase complex

C.1

1lpa

-22.1

8.7

89

1lpb

-26.2

10.3

87

Ganglioside GM2 activator

C.2

1tjj

-9.3

4.6

55

1pub

-7.8

5.2

44

Phosducin/βγ complex

C.3

1a0r

-3.7

2.7

45

2trc

-2.9

4.4

64

Tubby protein

C.4

1c8z

-4.2

6.2

87

1i7e

-3.6

2.6

78

  1. aAll structures were solved by X-ray crystallography.