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Table 7 Comparison of calculated energies (ΔG calc , kcal/mol), predicted penetration depths (D, Å) and protein tilts with respect to the membrane normal (τ, °) for alternative conformations of membrane-associated loops of different peripheral proteins.

From: The role of hydrophobic interactions in positioning of peripheral proteins in membranes

Protein Category Conformation 1a Conformation 2a
   PDB id Δ G calc D τ PDB id Δ G calc D τ
Signal peptidase A.1 1kn9 -4.5 4.5 83 1t7d -5.9 3.7 66
Cytochrome P450 2b4 A.1 1po5 -6.9 9.7 39 2bdm -18.2 10.5 45
Cytochrome P450 2c5 A.1 1nr6 -11.6 12.5 54 1dt6 -8.4 7.5 17
Cytochrome P450 2c9 A.1 1og5 -13.6 7.5 74 1r9o -10.7 7.5 57
Cytochrome P450 3a4 A.1 1tqn -20.7 10.2 61 1w0f -15.2 6.2 68
Bile-salt activated lipase C.1 1aql -9.7 6.0 80 1akn -6.6 5.7 67
Triacylglycerol lipase C.1 1tib -3.3 1.9 42 1dt5 -4.8 2.9 84
Lipase/colipase complex C.1 1lpa -22.1 8.7 89 1lpb -26.2 10.3 87
Ganglioside GM2 activator C.2 1tjj -9.3 4.6 55 1pub -7.8 5.2 44
Phosducin/βγ complex C.3 1a0r -3.7 2.7 45 2trc -2.9 4.4 64
Tubby protein C.4 1c8z -4.2 6.2 87 1i7e -3.6 2.6 78
  1. aAll structures were solved by X-ray crystallography.