Figure 1

Protein sequence with secondary structure assignments and topology diagram for vvUDG and comparison with human UDG. (A) Wiring plot for vvUDG. The figure shows the protein sequence overlaid with assigned secondary structure elements for the vvUDG monomer. The β-strands are labeled B1 through B10 and α helices are labeled H1 through H10. A β-hairpin turn between the two N-terminal β-strands B1 and B2 is also shown. The portions of the missing loop regions are indicated by spaces. Several residues of the N-terminal His-tag are visible in the structure. (B) Topology diagram for vvUDG. There are a total of 4 β-sheets (β-sheet 1: strands 1 and 2; β-sheet 2: strands 3 and 7; β-sheet 3: strands 4, 6, 8 and 9; β-sheet 4: strands 5 and 10). (C) Wiring plot for human UDG (PDBId: 1AKZ). The figure shows the protein sequence overlaid with assigned secondary structure elements for human UDG. (D) Topology diagram for human UDG (PDBId: 1AKZ). The figure was prepared using the PDBSUM server [39, 40].