Table 4 Characteristic motifs in UDGs (Example: E. coli UDG [2EUG] and human UDG [1AKZ]) and variations as seen in vvUDG (2OWQ, 2OWR).

Catalytic water-

62-GQDPYH-67

143-GQDPYH-148

66-GIDPYP-71

activating-loop

Pro-rich loop

84-AIPPS-88

165-PPPPS-169

-

Uracil specificity

120-LLLN-123

201-LLLN-204

117-IPWN-120

Gly-Ser loop

165-GS-166

246-GS-247

-

Leu intercalation loop

187-HPSPLSAHR-195

268-HPSPLSVYR-276

179-GYHPAARDR-187

Active site residues

D64, Y66, F77, N123, H187, L191

D145, Y147, F158, N204, H268, L272

D68, Y70, F79, N120, H181