Table 5 Possible allosteric disulfides in human fibronectin.
From: Search for allosteric disulfide bonds in NMR structures
Domain | Number | Disulfide | Configuration | DSE, kJ.mol-1 | Cα-Cα', Å | PDB ID |
|---|---|---|---|---|---|---|
Type 1 | 1st | 21–471 | -/+RHHook | 55.7 | 6.14 | 1o9a |
-RHSpiral | 24.8 | 6.32 | 1qgb | |||
45–56 | -LHStaple | 46.2 | 3.91 | 1o9a | ||
-RHStaple | 21.5 | 4.03 | 1qgb | |||
Type 1 | 2nd | 66–94 | -/+RHHook | 71.2 | 6.70 | 1o9a |
+LHHook | 40.5 | 6.51 | 1qgb | |||
92–104 | -RHStaple | 32.2 | 4.00 | 1o9a | ||
-LHStaple | 48.4 | 3.88 | 1qgb | |||
Type 1 | 4th | 155–184 | +/-RHSpiral | 27.9 | 5.59 | 1fbr |
182–194 | -RHStaple | 21.6 | 3.78 | 1fbr | ||
Type 1 | 5th | 200–229 | -RHSpiral | 12.4 | 5.59 | 1fbr |
227–239 | -RHStaple | 23.3 | 3.83 | 1fbr | ||
Type 1 | 6th | 277–304 | +/-RHSpiral | 25.6 | 6.09 | 1qo6 |
302–311 | -RHStaple | 23.2 | 3.60 | 1qo6 | ||
Type II | 1st | 329–355 | +/-LHHook | 12.2 | 5.85 | 1qo6 |
343–370 | -LHSpiral | 25.1 | 6.23 | 1qo6 |