Table 6 Features of the HIV gp 120 disulfide bonds
From: Search for allosteric disulfide bonds in NMR structures
Disulfide1 | Domain | Configurations2 | Overall DSE, kJ.mol-1 | Overall Cα-Cα', Å |
|---|---|---|---|---|
119–205 | spans V1/V2 | -LHHook (3) +/-RHHook (2) -LHStaple (1) -RHSpiral (1) -/+LHHook (1) | 23.5 ± 4.73 | 5.02 ± 0.134 |
126–196 | spans V1/V2 | -RHStaple (7) -RHHook (1) | 25.2 ± 2.4 | 4.37 ± 0.11 |
218–247 | within C2 | -RHStaple (8) | 15.4 ± 1.0 | 3.84 ± 0.04 |
228–239 | within C2 | -RHSpiral (5) +RHSpiral (2) +/-RHSpiral (1) | 12.2 ± 0.4 | 6.02 ± 0.06 |
296–331 | spans V3 | -RHStaple (8) | 14.6 ± 1.0 | 3.86 ± 0.04 |
378–445 | spans V4 | +/-RHSpiral (4) -RHSpiral (3) -/+RHHook (1) | 17.3 ± 2.2 | 6.30 ± 0.08 |
385–418 | spans V4 | -LHHook (5) -RHStaple (2) -LHStaple (1) | 28.2 ± 3.7 | 3.79 ± 0.03 |