Figure 4

Analysis of dimer interface. (A) Helices α6 after superimposition of the dimers of human IMPase (cyan) and SuhB (red) by secondary structure matching. The spacing of the helix axes is indicated in units of Å and the black oval indicates the position of the non-crystallographic 2-fold axis mapping the subunits onto each other. (B) The helix α6 interface in SuhB with side chains contributing to the contact surface indicated as sticks in cyan (subunit A) and yellow (subunit C). (C) Contact surface (magenta) of subunit A calculated and visualised using Swiss PDB Viewer [50]. The active site indicated by a molecule of inositol-1-phosphate (yellow sticks).