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Table 11 Spectrum of mutations in turns and bends in amino acid groupsa

From: Spectrum of disease-causing mutations in protein secondary structures

Amino acid group Original residues Expected residues χ2 P value Mutant residues Expected residues χ2 P value
Hydrophobic 80 105 6.02** 1.42E-02 151 160 0.50 4.80E-01
Positively charged 44 62 5.21* 2.24E-02 52 35 7.92** 4.88E-03
Negatively charged 96 68 11.94*** 5.48E-04 98 75 6.87** 8.78E-03
Conformational 152 102 24.95*** 5.90E-07 55 55 0.00 9.71E-01
Polar 53 81 9.44** 2.12E-03 62 79 3.58 5.85E-02
A+T 36 44 1.48 2.24E-01 43 56 3.20 7.34E-02
Sum 461 461    461 461   
  1. aχ2-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ2 are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.