Spectrum of disease-causing mutations in protein secondary structures

BMC Structural Biology

Table 11 Spectrum of mutations in turns and bends in amino acid groups^a

Amino acid group	Original residues	Expected residues	χ²	P value	Mutant residues	Expected residues	χ²	P value
Hydrophobic	80	105	6.02**	1.42E-02	151	160	0.50	4.80E-01
Positively charged	44	62	5.21*	2.24E-02	52	35	7.92**	4.88E-03
Negatively charged	96	68	11.94***	5.48E-04	98	75	6.87**	8.78E-03
Conformational	152	102	24.95***	5.90E-07	55	55	0.00	9.71E-01
Polar	53	81	9.44**	2.12E-03	62	79	3.58	5.85E-02
A+T	36	44	1.48	2.24E-01	43	56	3.20	7.34E-02
Sum	461	461			461	461

^aχ²-numbers in italics indicate underrepresentation and numbers in bold overrepresentation compared to random distribution based on amino acid frequencies. The results of the χ² are shown with significance level: * P < 0.05; ** P < 0.01; *** P < 0.001.

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